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Suspended Animation Study; No zombies here.
Topic Started: Jun 30 2005, 12:33 AM (244 Views)
somerled
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Admiral MacDonald RN
[/QUOTE]Suspended Animation Can Allow Survival without Brain Damage after Traumatic Exsanguination Cardiac Arrest of 60 Minutes in Dogs.

Quote:
 
Suspended Animation Can Allow Survival without Brain Damage after Traumatic Exsanguination Cardiac Arrest of 60 Minutes in Dogs.
Journal of Trauma-Injury Infection & Critical Care. 57(6):1266-1275, December 2004.
Nozari, Ala MD, PhD; Safar, Peter MD, FCCM; Wu, Xianren MD; Stezoski, William S.; Henchir, Jeremy BS; Kochanek, Patrick MD; Klain, Miroslav MD; Radovsky, Ann DVM, PhD; Tisherman, Samuel A. MD, FACS, FCCM
Abstract:
Background: We have previously shown in dogs that exsanguination cardiac arrest of up to 120 minutes without trauma under profound hypothermia induced by aortic flush (suspended animation) can be survived without neurologic deficit. In the present study, the effects of major trauma (laparotomy, thoracotomy) are explored. This study is designed to better mimic the clinical scenario of an exsanguinating trauma victim, for whom suspended animation may buy time for resuscitative surgery and delayed resuscitation.

Methods: Fourteen dogs were exsanguinated over 5 minutes to cardiac arrest. Flush of saline at 2[degrees]C into the femoral artery was initiated at 2 minutes of cardiac arrest and continued until a tympanic temperature of 10[degrees]C was achieved. The dogs were then randomized into a control group without trauma (n = 6) or a trauma group (n = 8) that underwent a laparotomy and isolation of the spleen before hemorrhage and then, at the start of cardiac arrest, spleen transection and left thoracotomy. During cardiac arrest, splenectomy was performed. After 60 minutes of no-flow cardiac arrest, reperfusion with cardiopulmonary bypass was followed by intensive care to 72 hours.

Results: All 14 dogs survived to 72 hours with histologically normal brains. All control dogs were functionally neurologically intact. Four of eight trauma dogs were also functionally normal. Four had neurologic deficits, although three required prolonged mechanical ventilation because of airway edema and evidence of multiple organ failure. Blood loss from the chest and abdomen was variable and was associated with poor functional outcomes.

Conclusion: Rapid induction of profound hypothermic suspended animation (tympanic temperature, 10[degrees]C) can enable survival without brain damage after exsanguination cardiac arrest of 60 minutes even in the presence of trauma, although prolonged intensive care may be required. This technique may allow survival of exsanguinated trauma victims, who now have almost no chance of survival.

© 2004 Lippincott Williams & Wilkins, Inc.


and

Survival without brain damage after clinical death of 60-120 mins in dogs using suspended animation by profound hypothermia. (Crit Care Med. 2003 May;31(5):1523-31.)Abstract : have to pay to view the entire paper (no I have not).
Quote:
 
Safar Center for Resuscitation Research, Pittsburgh, PA, USA.

OBJECTIVES: This study explored the limits of good outcome of brain and organism achievable after cardiac arrest (no blood flow) of 60-120 mins, with preservation (suspended animation) induced immediately after the start of exsanguination cardiac arrest.
DESIGN: Prospective experimental comparison of three arrest times, without randomization.
SETTING: University research laboratory.
SUBJECTS: Twenty-seven custom-bred hunting dogs (17-25 kg). INTERVENTIONS: Dogs were exsanguinated over 5 mins to cardiac arrest no-flow of 60 mins, 90 mins, or 120 mins. At 2 mins of cardiac arrest, the dogs received, via a balloon-tipped catheter, an aortic flush of isotonic saline at 2 degrees C (at a rate of 1 L/min), until tympanic temperature reached 20 degrees C (for 60 mins of cardiac arrest), 15 degrees C (for 60 mins of cardiac arrest), or 10 degrees C (for 60, 90, or 120 mins of cardiac arrest). Resuscitation was by closed-chest cardiopulmonary bypass, postcardiac arrest mild hypothermia (tympanic temperature 34 degrees C) to 12 hrs, controlled ventilation to 20 hrs, and intensive care to 72 hrs.
MEASUREMENTS AND MAIN RESULTS: We assessed overall performance categories
* (OPC 1, normal; 2, moderate disability; 3, severe disability; 4, coma; 5, death), * neurologic deficit scores (NDS 0-10%, normal; 100%, brain death), regional and * total brain histologic damage scores at 72 hrs (total HDS >0-40, mild; 40-100, moderate; >100, severe damage),
* and morphologic damage of extracerebral organs.
For 60 mins of cardiac arrest (n = 14), tympanic temperature 20 degrees C (n = 6) was achieved after flush of 3 mins and resulted in two dogs with OPC 1 and four dogs with OPC 2: median NDS, 13% (range 0-27%); and median total HDS, 28 (range, 4-36). Tympanic temperature of 15 degrees C (n = 5) was achieved after flush of 7 mins and resulted in all five dogs with OPC 1, NDS 0% (0-3%), and HDS 8 (0-48). Tympanic temperature 10 degrees C (n = 3) was achieved after flush of 11 mins and resulted in all three dogs with OPC 1, NDS 0%, and HDS 16 (2-18). For 90 mins of cardiac arrest (n = 6), tympanic temperature 10 degrees C was achieved after flush of 15 mins and resulted in all six dogs with OPC 1, NDS 0%, and HDS 8 (0-37). For 120 mins of cardiac arrest (n = 7), three dogs had to be excluded. In the four dogs within protocol, tympanic temperature 10 degrees C was achieved after flush of 15 mins. This resulted in one dog with OPC 1, NDS 0%, and total HDS 14; one with OPC 1, NDS 6%, and total HDS 20; one with OPC 2, NDS 13%, and total HDS 10; and one with OPC 3, NDS 39%, and total HDS 22.
CONCLUSIONS: In a systematic series of studies in dogs, the rapid induction of profound cerebral hypothermia (tympanic temperature 10 degrees C) by aortic flush of cold saline immediately after the start of exsanguination cardiac arrest-which rarely can be resuscitated effectively with current methods-can achieve survival without functional or histologic brain damage, after cardiac arrest no-flow of 60 or 90 mins and possibly 120 mins. The use of additional preservation strategies should be pursued in the 120-min arrest model.



Not as good a result as has be indicated elsewhere. Unfortunately , I am not prepared to pay $US20 to access the entire article to assess the voracity of the claims.
The resuscetated dogs were never actually dead , they were in a state of suspended animation (very deep form of coma).

The study also involved a very small sample of animals.

The story from News Corp was a hoax (or at the very least highly misleading) - no Zombie Dogs.
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Admiralbill_gomec
UberAdmiral
MODERATOR COMMENT

Somerled, please refrain from using the word hoax or making bets.

If you would like to discuss suspended animation, that's fine. Go for it. Enjoy. BUT, this is close to baiting.

This is NOT the politics forum. Please keep it civil.

END OF MODERATOR COMMENT
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captain_proton_au
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A Robot in Disguise

*Proton shakes head*


Somerled, you really hate admitting you were wrong dont you.


Firstly: Your main claim in the other thread was that this story was false


Secondly: The article from the other thread came from the Telegraphs 'Other Side' section, a section of short, interesting and yet fairly trivial news stories, the article was 300 words long and meant for the layman.

Distinctions between having their heart stopped for 1 hr and death are irrelevant
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Admiralbill_gomec
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Would anyone like to discuss the possibilities created by suspended animation?
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somerled
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Admiral MacDonald RN
Admiralbill_gomec
Jul 1 2005, 06:48 AM
Would anyone like to discuss the possibilities created by suspended animation?

Sure - care to start it off.

I think the research noted above is more related to battlefield and accident trauma treatment than long term suspended animation (for space exploration) , and from what they say above (if it can be extrapolated to humans - :shrug: ) very risky.

Likely that the crew would never revive , and any who did would be severely brain damaged.
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Admiralbill_gomec
UberAdmiral
Why don't you start.
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somerled
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Admiral MacDonald RN
Admiralbill_gomec
Jul 1 2005, 04:45 PM
Why don't you start.

:huh: Thought I did ????
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